DYNLL2

DYNLL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XQQ, 3P8M, 4D07, 1PWJ
Identifiers
Aliases	DYNLL2, DNCL1B, Dlc2, RSPH22, dynein light chain LC8-type 2
External IDs	OMIM: 608942; MGI: 1915347; HomoloGene: 115597; GeneCards: DYNLL2; OMA:DYNLL2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	58,095,542 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	87,878,359 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; myocardium of left ventricle; ; sperm; ; cardiac muscle tissue of right atrium; ; skin of arm; ; mucosa of ileum; ; pons; ; superior vestibular nucleus; ; pars compacta; ; ventral tegmental area;
	Top expressed in
	motor neuron; ; mammillary body; ; lateral hypothalamus; ; lateral geniculate nucleus; ; seminiferous tubule; ; ventromedial nucleus; ; medial vestibular nucleus; ; dorsomedial hypothalamic nucleus; ; cingulate gyrus; ; lateral septal nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytoskeletal motor activity; protein binding; plus-end-directed microtubule motor activity; dynein intermediate chain binding; dynein light intermediate chain binding; cytoskeletal protein binding; protein homodimerization activity; protein heterodimerization activity; scaffold protein binding;
Cellular component	cytoplasm; cytosol; nucleus; membrane; ciliary tip; centrosome; microtubule; plasma membrane; microtubule associated complex; dynein complex; cytoskeleton; mitochondrion; cilium; myosin V complex; cytoplasmic dynein complex; myosin complex; postsynaptic density; postsynapse; glutamatergic synapse;
Biological process	microtubule-based process; antigen processing and presentation of exogenous peptide antigen via MHC class II; endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; macroautophagy; intraciliary transport involved in cilium assembly; transport along microtubule; cilium assembly; sister chromatid cohesion; transport;
	Sources:Amigo / QuickGO
Orthologs
	140735
	68097
	ENSG00000264364
	ENSMUSG00000020483
	Q96FJ2
	Q9D0M5
	NM_080677
	NM_001168471; NM_001168472; NM_026556
	NP_542408
	NP_001161943; NP_001161944; NP_080832
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.^[5]^[6]

Interactions

DYNLL2 has been shown to interact with DLG4,^[7] C12orf40,^[8] DLGAP1,^[7] MYO5A^[7]^[9] and BMF.^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000264364 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020483 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, et al. (November 2005). "Cytoplasmic dynein nomenclature". The Journal of Cell Biology. 171 (3): 411–413. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
^ "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2".
^ ^a ^b ^c Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, et al. (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". The Journal of Neuroscience. 20 (12): 4524–4534. doi:10.1523/JNEUROSCI.20-12-04524.2000. PMC 6772433. PMID 10844022.
^ Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.
^ ^a ^b Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, et al. (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. 293 (5536): 1829–1832. Bibcode:2001Sci...293.1829P. doi:10.1126/science.1062257. PMID 11546872. S2CID 5638023.
^ Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, et al. (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". The Biochemical Journal. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.

External links

Overview of all the structural information available in the PDB for UniProt: Q96FJ2 (Dynein light chain 2, cytoplasmic) at the PDBe-KB.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000264364 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020483 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16260502-5] Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, et al. (November 2005). "Cytoplasmic dynein nomenclature". The Journal of Cell Biology. 171 (3): 411–413. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.

[entrez-6] "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2".

[pmid10844022-7] Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, et al. (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". The Journal of Neuroscience. 20 (12): 4524–4534. doi:10.1523/JNEUROSCI.20-12-04524.2000. PMC 6772433. PMID 10844022.

[8] Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, et al. (November 2014). "A proteome-scale map of the human interactome network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.

[pmid11546872-9] Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, et al. (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. 293 (5536): 1829–1832. Bibcode:2001Sci...293.1829P. doi:10.1126/science.1062257. PMID 11546872. S2CID 5638023.

[pmid14561217-10] Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, et al. (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". The Biochemical Journal. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.

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DYNLL2

Interactions

References

Further reading

Further reading

External links